Chun-Chao Chang, M.D.


• Gastrointestinal diseases
• Hepatitis
• Endoscopy
• Sonography
• Cancer

• English
• Chinese



  • Taipei Medical University, MD.
  • Taipei Medical University Graduate Institute of Medical Sciences, MS



  • Vice Superintendent, Taipei Medical University Hospital (2017.08~present)
  • Attending Physician, Division of Gastroenterology and Hepatology, Taipei Medical University Hospital (1996.07~present)
  • Professor, Division of Gastroenterology and Hepatology, Taipei Medical University (2016.02~present)



  • Chao KC, Chang CC, Owaga E, Bai CH, Huang TC, Pan WH, Chang JS(2016).Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents. Public Health Nutr. 2016 Apr;19(6):1067-73//.(6):1067-73.
  • Chao KC, Chang CC, Owaga E, Bai CH, Huang TC, Pan WH, Chang JS(2016).Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents. Public Health Nutr. 2016 Apr;19(6):1067-73//.(6):1067-73.
  • Cheng CC, Guan SS, Yang HJ, Chang CC, Luo TY, Chang J, Ho AS(2016).Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer. J Biomed Sci. 2016 Jan 28;23(1):18//.(1):18-.
  • Tai CJ, Wang CK, Tai CJ, Tzao C, Lien YC, Hsieh CC, Hsieh CI, Wu HC, Wu CH, Chang CC, Chen RJ, Chiou HY(2016).Evaluation of Safety and Efficacy of Salvage Therapy With Sunitinib, Docetaxel (Tyxane) and Cisplatinum Followed by Maintenance Vinorelbine for Unresectable/Metastatic Nonsmall Cell Lung Cancer: Stage 1 of a Simon 2 Stage Clinical Trial. Medicine (Baltimore). 2015 Dec;94(52):e2303//.(52):e2303-.
  • Huang CJ, Lee CL, Yang SH, Chien CC, Huang CC, Yang RN, Chang CC(2016).Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system. Biochim Biophys Acta. 2016 Apr 13. pii: S0925-4439(16)30081-3//.(16):30081-3.
  • Tai CJ, Huang MT, Wu CH, Wang CK, Tai CJ, Chang CC, Hsieh CI, Chang YJ, Wu CJ, Kuo LJ, Wei PL, Chen RJ, Chiou HY(2016).Combination of Two Targeted Medications (Bevacizumab Plus Cetuximab) Improve the Therapeutic Response of Pancreatic Carcinoma. Medicine (Baltimore). 2016 Apr;95(15):e3259//.(95):e3259-.
  • Tai CJ, Wang H, Wang CK, Tai CJ, Huang MT, Wu CH, Chen RJ, Kuo LJ, Wei PL, Chang YJ, Chang CC, Chiou HY, Wu CJ(2016).Bevacizumab and cetuximab with conventional chemotherapy reduced pancreatic tumor weight in mouse pancreatic cancer xenografts. Clin Exp Med. 2016 Mar 19. [Epub ahead of print]//.():-.
  • Liou JM, Bair MJ, Chen CC, Lee YC, Chen MJ, Chen CC, Tseng CH, Fang YJ, Lee JY, Yang TH, Luo JC, Wu JY, Chang WH, Chang CC, Chen CY, Chen PY, Sh(2016).Levofloxacin Sequential Therapy vs Levofloxacin Triple Therapy in the Second-Line Treatment of Helicobacter pylori: A Randomized Trial. Am J Gastroenterol. 2016 Mar;111(3):381-7//.(111):381-7.
  • Kao WY, Chao Y, Chang CC, Li CP, Su CW, Huo TI, Huang YH, Chang YJ, Lin HC, Wu JC(2015).Prognosis of Early-Stage Hepatocellular Carcinoma: The Clinical Implications of Substages of Barcelona Clinic Liver Cancer System Based on a Cohort of 1265 Patients. Medicine (Baltimore). 2015 Oct;94(43):e1929//.(43):e1929-.
  • Liou JM, Chen CC, Chang CY, Chen MJ, Chen CC, Fang YJ, Lee JY, Yang TH, Luo JC, Wu JY, Liou TC, Chang WH, Hsu YC, Tseng CH, Chang CC, Bair MJ, Liu(2015).Sequential therapy for 10 days versus triple therapy for 14 days in the eradication of Helicobacter pylori in the community and hospital populations: a randomised trial. Gut. 2015 Sep 3. pii: gutjnl-2015-310142//.():-.
  • Wang CK, Lin YF, Tai CJ, Wang CW, Chang YJ, Choong CY, Lin CS, Tai CJ, Chang CC(2015).Integrated Treatment of Aqueous Extract of Solanum nigrum-Potentiated Cisplatin- and Doxorubicin-Induced Cytotoxicity in Human Hepatocellular Carcinoma Cells. Evid Based Complement Alternat Med. 2015;2015:675270//.(2015):1-9.
  • Liou JM, Chang CY, Chen MJ, Chen CC, Fang YJ, Lee JY, Wu JY, Luo JC, Liou TC, Chang WH, Tseng CH, Wu CY, Yang TH, Chang CC, Wang HP, Sheu BS, Lin(2015).The Primary Resistance of Helicobacter pylori in Taiwan after the National Policy to Restrict Antibiotic Consumption and Its Relation to Virulence Factors-A Nationwide Study. PLoS One. 2015 May 5;10(5):e0124199//.(5):e01241-.
  • Chen MC, Chang CJ, Lu YH, Niu DM, Lou HY, Chang CC(2015).R173W mutation of hydroxymethylbilane synthetase is associated with acute intermittent porphyria complicated with rhabdomyolysis: the first report. J Clin Gastroenterol. 2015 Mar;49(3):256-7.(3):256-7.
  • Quyen TTB, Chang CC, Su WN, Pan CJ, Liu JY, Rick J, Lin KY, Hwang BJ(2014).Self-focusing Au@SiO2 nanorods with rhodamine6G as highly sensitive SERS substrate forcarcinoembryonic antigen detection. Jourmal of Materials Chemistry B.():-.
  • Kuo HF, Chang CC(2014).Analysis of Core-Shell-Isolated NanoparticleConfigurations Used in the Surface-EnhancedRaman Scattering Technique. IEEE SENSORS JOURNAL.(14):3708-3714.
  • Mai FD, Yu CC, Liu YC, Chang CC, Yang KH(2014).Highly effective surface-enhanced Raman scattering-active goldsubstrates prepared by using electrochemical methods in the presenceof hexadecyltrimethylammonium bromide. Journal of Electroanalytical Chemistry.(712):96-102.
  • Chang JS, Chang CC, Chien EY, Lin SS, Cheng-Shiuan T, Bai CH, Chao KC.(2013).Association between interleukin 1beta and interleukin 10 concentrations: a cross-sectional study in young adolescents in Taiwan. BMC Pediatr.():-.
  • Kao SS, Chen WC, Hsu PI, Chuah SK, Lu CL, Lai KH, Tsai FW, Chang CC, Tai WC(2013).The Frequencies of Gastroesophageal and Extragastroesophageal Symptoms in Patients with Mild Erosive Esophagitis, Severe Erosive Esophagitis, and Barrett's Esophagus in Taiwan. Gastroenterol Res Pract.():-.
  • Tai CJ,Su TC, Jiang MC, Chen HC, Shen SC, Lee WR, Liao CF, Chen YC, Lin SH, Li LT, Shen KH, Yeh CM, Yeh KT, Lee CH, Shih HY, Chang CC(2013).Correlations between cytoplasmic CSE1L in neoplastic colorectal glands and depth of tumor penetration and cancer stage. J Transl Med.(11):1-10.
  • Jiang MC, Yeh CM, Tai CJ, Chen HC, Lin SH, Su TC, Lee CH, Shen SC, Lee WR, Liao CF, Li LT, Chen YC, Yeh KT, Chang CC(2013).CSE1L modulates Ras-induced cancer cell invasion: Correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression. The American Journal of Surgery.(3):418-27.
  • Quyen TTB, Su WN, Chen KJ, Pan CJ, Ricj J, Chang CC, Hung BJ(2013).Au@SiO2 core/shell nanoparticle assemblage used for highly sensitive SERS-baseddetermination of glucose and uric acid. J. Raman Spectrosc.():-.
  • Chen KJ, Su WN, Pan CJ, Cheng SY, Rick J, Wang SH, Liu CC, Cahng CC,Yang YW,Wang CH, Hwang BJ(2013).Dendritic platinum-decorated gold nanoparticles for non-enzymatic glucose biosensing†. Journal of Materials Chemistry B.():-.
  • Tai CJ, Wang CK, Tai CJ, Lin YF, Lin CS, Jian JU, Chang YJ, Chang CC(2013).Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine.(17):1-12.
  • Chang CC, Yang KH, Liu YC, Yu CC.(2012).Surface-enhanced Raman scattering-active silver nanostructures with two domains. Anal Chim Acta.(4):91-97.
  • Chang CC, Tai CJ, Su TC, Shen KH, Lin SH, Yeh CM, Yeh KT, Lin YM, Jiang MC(2012).The prognostic significance of nuclear CSE1L in urinary bladder urothelial carcinomas. Ann Diagn Pathol.():-.
  • Chang CC, Yang KH, Liu YC, Yu CC, Wu YH.(2012).Surface-enhanced Raman scattering-active gold nanoparticles modified with a monolayer of silver film. Analyst.(137):4943-4950.
  • Chang CC, Yang KH, Liu YC, Hsu TC, Mai FD(2012).Surface-enhanced Raman scattering-active Au/SiO2 nanocomposites prepared using sonoelectrochemical pulse deposition methods. ACS Appl Mater Interfaces.(4):4700-4707.
  • Chang CC, Yang KH, Liu YC, Hsu TC(2012).New pathway to prepare gold nanoparticles and their applications in catalysis and surface-enhanced Raman scattering. Colloids Surf B Biointerfaces.(93):169-173.
  • Tai CJ, Chang CC, Jiang MC, Yeh CM, Su TC, Wu PR, Chen CJ, Yeh KT, Lin SH, Chen HC.(2012).Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer. Pol J Pathol.(63):93-100.
  • Kuo LJ, Chiou JF, Tai CJ, Chang CC, Kung CH, Lin SE, Hung CS, Wang W, Tam KW, Lee HC, Liang HH, Chang YJ, Wei PL.(2012).Can we predict pathologic complete response before surgery for locally advanced rectal cancer treated with preoperative chemoradiation therapy?. Int J Colorectal Dis.(27):613-621.
  • Chang HM, Liao WC, Sheu JN, Chang CC, Lan CT, Mai FD(2012).Sleep Deprivation Impairs Ca2+ Expression in the Hippocampus: Ionic Imaging Analysis for Cognitive Deficiency with TOF-SIMS. Microsc Microanal.(12):1-11.
  • Cheng CC, Lu N, Peng CL, Chang CC, Mai FD, Chen LY, Liao MH, Wang WM, Chang J.(2012).Targeting to overexpressed glucose-regulated protein 78 in gastric cancer discovered by 2D DIGE improves the diagnostic and therapeutic efficacy of micelles-mediated system. Proteomics.(12):2584-2597.
  • Hsu YC, Chiu HM, Liou JM, Chang CC, Lin JT, Liu HH, Wu MS(2012).Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia. Cancer Causes Control.(23):321-328.
  • Tai CJ, Liao CF, Su TC, Shen KH, Chang CC, Lin SH, Yeh CM, Shen SC, Lee WR, Chiou JF, Lin CH, Chen YC, Shih HY, Yeh KT, Jiang MC.(2012).Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas. Int J Biol Markers.():-.
  • Liao CF, Lin SH, Chen HC, Tai CJ, Chang CC, Yeh CM, Yeh KT, Chen YC, Hsu TH, Shen SC, Lee WR, Chiou JF, Luo SF, Jiang MC.(2012).CSE1L, a novel microvesicle membrane protein, mediates Ras-triggered microvesicle generation and metastasis of tumor cells. Mol Med.():-.
  • Cheng CC, Chang J, Chen LY, Ho AS, Huang KJ, Lee SC, Mai FD, Chang CC(2012).Human neutrophil peptides 1-3 as gastric cancer tissue markers measured by MALDI-imaging mass spectrometry: Implications for infiltrated neutrophils as a tumor target. Dis Markers.(32):21-31.
  • Tai CJ, Lee CH, Chen HC, Wang HK, Jiang MC, Su TC, Shen KH, Lin SH, Yeh CM, Chen CJ, Yeh KT, Chang CC.(2012).High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer. Ann Diagn Pathol.():-.
  • Chang CC, Hsu TC, Liu YC, Yang KH.(2011).Surface-enhanced Raman scattering-active silver substrates electrochemically prepared in solutions containing bielectrolytes. J Mater Chem.(21):6660-6667.
  • Liu SL, Cheng CC, Chang CC, Mai FD, Wang CC, Lee SC, Ho AS, Chen LY, Chang J(2011).Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein. J Biomed Sci.(1):52-.
  • Huang SM, Chien LY, Chang CC, Chen PH, Tai CJ(2011).Abnormal gastroscopy findings were related to lower meridian energy. Evid Based Complement Alternat Med.(2011):878391-.
  • Huang CJ, Yang SH, Huang SM, Lin CM, Chien CC, Chen YC, Lee CL, Wu HH, Chang CC(2011).A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment. J Transl Med.(28):982-989.