Hsi-Hsien Chen, MD PhD


• Edema
• Proteinuria
• Acute/chronic kindy failure
• Hypertension
• Electrolyte imbalance
• Hemodialysis
• Peritoneal dialysis
• Kidney transplantation

• English
• Chinese



  • 1987-1994 M.D., Taipei Medical College
  • 2004-2010 Ph.D., Graduate Institute of Clinical Medicine, Taipei Medical University



  • 1996-1999 Resident, Department of Internal Medicine, TMUH
  • 1999-2001 Chief Resident, Division of Nephrology, Department of Internal Medicine, TMUH
  • 2002-2003 Fellowship, Division of Nephrology, UT Southwestern Medical Center at Dallas
  • 2001- Attending physician, Division of Nephrology, Department of Internal Medicine, TMUH
  • 2012- Director, Division of Nephrology, Department of Internal Medicine, TMUH



  • Hsiao-Chien Chen, Chung-Yi Cheng, Hsiu-Chen Lin, Hsi-Hsien Chen, Cheng-Hsien Chen,Chih-Ping Yang, Kai-Huei Yang, Chun-Mao Lin, Tsung-Yao Lin, Chwen-Ming Shih, Yu-Chuan Liu. Multifunctions of Excited Gold Nanoparticles Decorated Artificial Kidney with Efficient Hemodialysis and Therapeutic Potential ACS Applied Materials & Interfaces 2016(8):19691–19700
  • Hsi-Hsien Chen#, Yi-Fan Lan#, Hsiao-Fen Li, Ching-Feng Cheng, Pei-Fang Lai, Wei-Hua Li, Heng Lin. Urinary miR-16 transactivated by C/EBPβ reduces kidney function after ischemia/reperfusion–induced injury Scientific Reports 2016(6):27945.
  • Chih-Chin Kao ,Jui-Yuan Hung, Shu-Ching Yeh, Chiao-Ying Hsu, Yen-Chung Lin, Tzen-Wen Chen, Hsi-Hsien Chen*. Tacrolimus-induced acute demyelinating sensorimotor polyneuropathy with axonal damage after kidney transplantation Acta Nephrologica 2015(29):176-180.
  • Mansoureh Z. Mousavi, Huai-Yi Chen, Kuang-Li Lee, Heng Lin, Hsi-Hsien Chen, Yuh-Feng Lin, Chung-Shun Wong, Hsiao Fen Li, Pei-Kuen Weia, Ji-Yen Cheng. Urinary micro-RNA biomarker detection using capped gold nanoslit SPR in a microfluidic chip Analyst 2015(140):4097-4104.
  • Chen HH, Lai PF, Lan YF, Cheng CF, Zhong WB, Lin YF Chen TW Lin H. Exosomal ATF3 RNA Attenuates Pro-Inflammatory Gene MCP-1 Transcription in Renal Ischemia-Reperfusion Journal of Cellular Physiology 2014(229):1202-1211.
  • Lin H, Li HF, Chen HH, Lai PF, Juan SH, Chen JJ Cheng CF. Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathway Molecular Pharmacology 2014(85):682-691.
  • Chen HC, Lin HC, Chen HH, Mai FD, Liu YC, Lin CM, Chang CC, Tsai HY, Yang CP. Innovative strategy with potential to increase hemodialysis efficiency and safety Scientific Reports 2014(4):4425.
  • Lin H, Li HF, Lian WS, Chen HH, Lan YF, Lai PF, Cheng CF. Thromboxane A2 Mediates Iron-Overload Cardiomyopathy in Mice Through Calcineurin-Nuclear Factor of Activated T Cells Signaling Pathway Circulation Journal 2013(77):2586-2595.
  • Lia PF, Cheng CF, Lin H, Tseng TL, Chen HH, Chen SH. ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression Evidence-Based Complementary and Alternative Medicine 2013():716481.
  • Lin H, Lian WS, Chen HH, Lai PF, Cheng CF. Adiponectin ameliorates iron-overload cardiomyopathy through the PPARα-PGC-1-dependent signaling pathway Molecuar Pharmacology 2013(84):275-285.
  • Yi-Fan Lan#, Hsi-Hsien Chen#, Pei-Fang Lai, Ching-Feng Cheng, Yen-Ta Huang, Yi-Chao Lee, Tzen-Wen Chen, Heng Lin. MicroRNA-494 Reduces ATF3 Expression and Promotes AKI JASN 2012(23):2012-2023.
  • Chung-Te Liu, Tso-Hsiao Chen, Hsi-Hsien Chen,Y en-Chung Lin, Tzen-Wen Chen. Effect of Sitagliptin on Blood Pressure and Estimated Glomerular Filtration Rate in Diabetic Patients Using an Angiotensin II Receptor Blocker Journal of Experimental and Clinical Medicine 2012(4):334-337.
  • Te-Chih Wong, Yu-Tong Chen, Pei-Yu Wu, Tzen-Wen Chen, Hsi-Hsien Chen, Tso-Hsiao Chen, Shwu-Huey Yang. Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids Independently Related to Muscle Mass Decline in Hemodialysis Patients plos one 2015(10):e01404-.
  • Chiu YF, Chen YC, Wu PY, Shih CK, Chen HH, Chen TH Yang SH. Association between the hemodialysis eating index and risk factors of cardiovascular disease in hemodialysis patients Journal of Renal Nutrition 2014(24):163-171.