Chang, Wei-Chin, MD, PhD

Pathology

SPECIALTY/PRACTICE AREAS：
• Thoracic pathology
• Surgical pathology
• Cytopathology
• Molecular pathology
LANGUAGES SPOKEN：
• English
• Chinese

PROFESSIONAL EDUCATION

•  PhD, Institute of Clinical Medicine, National Yang-Ming Chiao Tung University

•  MD, School of Medicine, Taipei Medical University

 

ADMINSTRATIVE APPOINTMENTS

•  Chief, Department of Pathology, Taipei Medical University Hospital

•  Assistant Professor, Department of Pathology, Taipei Medical University

 

PUBLICATIONS

1. Kao HL, Chang WC, Li WY, Li ACH, Li AFY. Head and neck large cell neuroendocrine carcinoma should be separated from atypical carcinoid on the basis of different clinical features, overall survival, and pathogenesis. Am J Surg Pathol. 2012;36(2):185-92.

2. Chang WC, Chang YH, Pan CC. Prognostic significance in substaging of T1 urinary bladder urothelial carcinoma on transurethral resection. Am J Surg Pathol. 2012;36(3):454-61.

3. Chang WC, Chen JY, Lee CH, Yang AH. Expression of decoy receptor 3 in diffuse sclerosing variant of papillary thyroid carcinoma: correlation with M2 macrophage differentiation and lymphatic invasion. Thyroid. 2013;23(6):720-6.

4. Liang WY, Chang WC, Hsu CY, Arnason T, Berger D, Hawkins AT, Sylla P, Lauwers GY. Retrospective evaluation of elastic stain in the assessment of serosal invasion of pT3N0 colorectal cancers. Am J Surg Pathol. 2013;37(10):1565-70.

5. Liang PI, Chang ST, Lin MY, Hsieh YC, Chu PY, Chen CJ, Lin KJ, Jung YC, Hwang WS, Huang WT, Chang WC, Ye H, Chuang SS. Angioimmunoblastic T-cell lymphoma in Taiwan shows a frequent gain of ITK gene. Int J Clin Exp Pathol. 2014;7(9):6097-107.

6. Huang CC, Hung ST, Chang WC, Sheu CY. Benign features of infection-related tumor-like lesions of the lung: A retrospective imaging review study. J Med Imaging Radiat Oncol. 2017;61(4):481-488

7. Kao YC, Fletcher CDM, Alaggio R, Wexler L, Zhang L, Sung YS, Orhan D, Chang WC, Swanson D, Dickson BC, Antonescu CR. Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas: Expanding the Genetic Spectrum of Tumors With Overlapping Features With Infantile Fibrosarcoma. Am J Surg Pathol. 2018;42(1):28-38.

8. Lee TF, Tseng YC, Chang WC, Chen YC, Kao YR, Chou TY, Ho CC, Wu CW. YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas. Oncotarget. 2017 Jul 27;8(52):89539-8955

9. Chang WC, Yeh YC, Ho HL, Hsieh SL, Chou TY. Decoy Receptor 3 Expression Is Associated With Wild-Type EGFR Status, Poor Differentiation of Tumor, and Unfavorable Patient Outcome: Clinicopathologic Analysis of 461 Lung Adenocarcinomas. Am J Clin Pathol. 2019 Jul 5;152(2):207-216

10. Antonescu CR, Dickson BC, Swanson D, Zhang L, Sung YS, Kao YC, Chang WC, Ran L, Pappo A, Bahrami A, Chi P, Fletcher CD. Spindle Cell Tumors With RET Gene Fusions Exhibit a Morphologic Spectrum Akin to Tumors With NTRK Gene Fusions. Am J Surg Pathol. 2019 Oct;43(10):1384-1391.

11. Wang YJ, Chang WC, Wang JY, Wu YH. Ex vivo full-field cellular-resolution optical coherence tomography of basal cell carcinomas: A pilot study of quality and feasibility of images and diagnostic accuracy in subtypes. Skin Res Technol. 2020 Mar;26(2):308-316.

12. Yang HW, Su YJ, Chang WC. Acute Abdomen Caused by Ruptured Angiomatoid Fibrous Histiocytoma. International Journal of Gerontology. 2020 May;14:146-148.

13. Chang WC, Zhang YZ, Lim E, Nicholson AG. Prognostic Impact of Histopathologic Features in Pulmonary Invasive Mucinous Adenocarcinomas: Proposal for a Pathologic Grading System. Am J Clin Pathol. 2020; Jun 8;154(1):88-102.

14. Chang CY, Chen PH, Hou MC, Chang WC, Yang TC, Hsin IF, Liao WC, Lee FY. Magnifying Endoscopy With Narrow-Band Image for Diagnosing Diffuse Type of Gastric Antral Vascular Ectasia in Cirrhotic Patients. Eur J Gastroenterol Hepatol. 2021;33(4);495-500.

15. Chang WC, Zhang YZ, Wolf JL, Hermelijn SM, Schnater JM, von der Thüsen JH, Rice A, Lantuejoul S, Mastroianni B, Farver C, Black F, Popat S, Nicholson AG. Mucinous adenocarcinoma arising in congenital pulmonary airway malformation: Clinicopathological analysis of 37 cases. Histopathology. 2021;78(3):434-444.

16. Lee TF, Liu YP, Lin YF, Hsu CF, Lin H, Chang WC, Pan CM, Chou TY, Wu CW. TAZ negatively regulates the novel tumor suppressor ANKRD52 and promotes PAK1 dephosphorylation in lung adenocarcinomas. Biochim Biophys Acta Mol Cell Res. 2021 Feb;1868(2):118891.

17. Yen CT, Wu WJ, Chen YT, Chang WC, Yang SH, Shen SY, Su J, Chen HY. Surgical resection of brain metastases prolongs overall survival in non-small-cell lung cancer. Am J Cancer Res. 2021 Dec 15;11(12):6160-6172.

18. Wu WJ, Yang SH, Chung HP, Yen CT, Chen YT, Chang WC, Su J, Chen HY. EGFR Q787Q Polymorphism Is a Germline Variant and a Prognostic Factor for Lung Cancer Treated With TKIs. Front Oncol. 2022 Mar 21;12:816801.

19. Hsia Y, Huang HC, Chang WC. Comparison of Different Hepatocyte Nuclear Factor 4α Clones for Invasive Mucinous Adenocarcinoma of the Lung. Appl Immunohistochem Mol Morphol. 2022 May-Jun 01;30(5):383-388. (Corresponding author)

20. Chang WC, Yeh YC, Ho HL, Chou TY. Deep exploration of immune function in EGFR wild-type and mutated lung adenocarcinomas by gene expression profiling: role of TRAIL-R2 (TNFRSF10B) in patient treatment and outcome. Hum Pathol. 2022 Aug;126:9-18.

21. Su NW, Mok LM, Chan ML, Liu HC, Chang WC, Yun CH, Shieh TY, Wu MC, Lin HC, Huang WC, Chen YJ. Impact of Perineural Invasion and Preexisting Type 2 Diabetes on Patients with Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Chemoradiotherapy. Cancers (Basel). 2023 Feb 9;15(4):1122.

22. Chang WC, Zhang YZ, Nicholson AG. Pulmonary invasive mucinous adenocarcinoma. Histopathology. 2024 Jan;84(1):18-31. (Review)

23. Liu HC, Lin MH, Chang WC, Zeng RC, Wang YM, Sun CW. Rapid On-Site AI-Assisted Grading for Lung Surgery Based on Optical Coherence Tomography. Cancers (Basel). 2023 Nov 13;15(22):5388.