Nan-Chung Chang, MD PhD

Cardiology

SPECIALTY/PRACTICE AREAS：
• Cardiology
• Internal medicine
• Geriatric medicine
LANGUAGES SPOKEN：
• English
• Chinese

 

PROFESSIONAL EDUCATION：

• MD, Taipei Medical University
• PhD, Juntendo University

 

ADMINSTRATIVE APPOINTMENTS：

• Attending Physician, Department of Internal Medicine, Taipei Medical University Hospital, Taipei(1986.12 - present)
• Chairman, Department of Internal Medicine, Taipei Medical University Hospital, Taipei (2003.9 - 2007.9)
• Vice-Superintendent (Academic and Education Affairs), Taipei Medical University Hospital, Taipei (2002.12 - 2003.8)
• Chief, Section of Geriatric Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei(2003.9 - 2008.9)
• Chief, Section of Cardiovascular Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei (1991.8 - 2007.9)
• Chief, Intensive Care Unit, Taipei Medical University Hospital, Taipei (1991.3 - 1997.7)
• Attending Physician, Department of Cardiovascular Diagnostic Radiology, Nihon University Hospital, Tokyo, Japan (1986.4 – 1986.11)
• Attending Physician, Department of Cardiology, Juntendo University Hospital, Tokyo, Japan (1985.4-1986.3)

 

PUBLICATIONS：

• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2017).Nicorandil Regulates the Macrophage Skewing and Ameliorates Myofibroblasts by Inhibition of RhoA/Rho-kinase Signaling in Infarcted Rats. Journal of Cellular and Molecular Medicine. Jan 17 accepted, 2017.DOI:10.1111/jcmm.13130//.():1-15.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2017).Effect of lithium on ventricular remodeling in infarcted rats via the Akt/mTOR signaling pathways. Bioscience Rep. Jan 2017 accepted, DOI: 10.1042/BSR20160257/.():-.
• Wang Mei-Yeh, Chang Nen-Chung, Hsieh Ming-Hsiung, Su Chien-Tien, Liu Ju-Chi, Shyu Yuh-Kae,Tsai Pei-Shan(2016).Effect of Feedback Signal on Blood Pressure Self-regulation Capability in Individuals With Prehypertension or Stage I Hypertension. A Randomized Controlled Study. Journal of Cardiovascular Nursing. Mar 2016. 2016; 31(2):166-172//.(31):166-172.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2016).Effects of urate-lowering agents on arrhythmia vulnerability in post-infarcted rat hearts. Journal of Pharmacological Sciences. 2016 May. 2016;131（１）：28-36//.(131):28-36.
• Lee Tsung-Ming, Chen Wei-Ting, Chang Nen-Chung(2016).Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats. Biosci. Rep. Mar 16, 2016 / 36(2) /e00307 / doi 10.1042/BSR20150139.():-.
• Wei Jih-Hua, Chang Nen-Chung, Chen Sy-Ping, GeraldinePitchairaj, JayakumThanasekaran, Fong Tsorng-Harn(2015).Comparative decline of the protein profiles of nebulin in response to denervation in skeletal muscle. （Wei Jih-Hua and Chang Nen-Chung are first authors with equal contribution）. Biochemical and Biophysical Research Communications. 2015; 466（1）：95-102, October 9, 2015//.(466):95-102.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2015).Inhibition of glycogen synthase kinase-3b prevents sympathetic hyperinnervation in infarcted rats. Experimental Biology and Medicine. 2015 Jul;2015;240(7):979-992//.(7):979-992.
• Lee Tsung-Ming, Chen Wei-Ting, Chang Nen-Chung(2015).Dipeptidyl Peptidase-4 Inhibition Attenuates Arrhythmias via a Protein Kinase A-Dependent Pathway in Infarcted Hearts. Circulation Journal. Nov. 2015. 2015; 79(11): 2461-2470//.(79):2461-2470.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-chung(2015).Both GPER and membrane oestrogen receptor-a activation protect ventricular remodelling in 17b oestradiol-treated ovariectomized infarcted rats. J. Cell. Mol. Med. 2014;18 （12）：2454-2465//.(18):2454-2465.
• Hung Ming-Jui, Hsu Kuang-Hung, Chang Nen-Chung, Tsimikas Sotirios, Hung Ming-Yow(2015).Prevalence of coronary artery spasm after stent placement and its association with inflammation. International Journal of Cardiology, Jan 2015；179：252-255//.(179):252-255.
• Chiang Shuo-Ju, Daimon Masao, Wang Li-Hsuan, Hung Ming-Jui, Chang Nen-Chung, Lin Hsiu-Chen(2015).Association between mitral valve prolapse and open-angle glaucoma. Heart, doi:10.1136/heartjnl-2014-306198.():-.
• Lu Wan-Jung, Chang Nen-Chung, Jayakumar Thanasekar, Liao Jiun-Cheng, Lin Mei-Jiun, Wang Shwu-Huey, Chou Duen-Suey, Thomas Philip Aloysius, Sheu Joen-Rong(2014).Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP. （Dr. Lu Wan-Jung and Dr. Chang Nen-Chung contributed equally in this work）Thrombosis Research. Dec 2014;134（6）：1301-1310//.(134):1301-1310.
• Hung Ming-Jui, Hsu Kuang-Hung, Chang Nen-Chung, Hung Ming-Yow(2014).Increased Numbers of Coronary Events in Winter and Spring Due to Coronary Artery Spasm: Effect of Age, Sex, Smoking and Inflammation. Journal of the American College of Cardiology. accepted.(-):---.
• Tsung-MingLee, Lin Shinn-Zong, Chang Nen-Chung(2014).Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1signaling. Free Radical Biology and Medicine, Dec 2014;　77：71–81//.(77):71-81.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2014).Effect of Cilostazol on Sympathetic Hyperinnervation in Healed Rat Infarcts. Circ J . On line: doi :10.1253/circj.CJ-13-0749 (Dec 4, 13).():-.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2014).Membrane ERα attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats. J Mol Med. 2014 Jan, 2014;92(1):43-51//.(92):43-51.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2014).Differential Effect of Phosphodiesterase-3 Inhibitors on Sympathetic Hyperinnervation in Healed Rat Infarcts. Circ J. 2014 Feb., 2014; 78(2)：366-376.//.(78):366-376.
• Lee Tsung-Ming, Chung Tun-Hui, Lin Shinn-Zong, Chang Nen-Chung(2014).Endothelin Receptor Blockade Ameliorates Renal Injury by Inhibition of RhoA/Rho-kinase Signalling in DOCA-salt Hypertensive Rats. J Hypertens 2014 Apr., 2014; 32(4)：795-805. //.(32):795-805.
• Chang Yi, Chang Tien-Chen, Lee Jie-Jen, Chang Nen-Chung, Huang Yung-Kai(2014).Sanguis draconis, a Dragon’s Blood Resin, Attenuates High Glucose-Induced Oxidative Stress and Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. Scientific World Journal, 2014 June, Volume 2014, Article ID 423259, 10 pages, http://dx.doi.org/10.1155/2014/423259 //.(2014):1-10.
• Chang Yi, Chang Tien-Chen, Lee Jie-Jen, Chang Nen-Chung, Huang Yung-Kai(2014).Sanguis draconis, a Dragon’s Blood Resin, Attenuates High Glucose-Induced Oxidative Stress and Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. Scientific World Journal, Volume 2014 (2014), Article ID 423259, 10 pages, http://dx.doi.org/10.1155/2014/423259 //.(2014):1-10.
• Shih Chun-Ming, Chen Yung-Hsiung, Lin Yi-Wen, Chang Nen-Chung, Lin Feng-Yen(2014).MK-0626, A Dipeptidyl Peptidase-4 Inhibitor, Improves Neovascularization by Increasing Both the Number of Circulating Endothelial Progenitor Cells and Endothelial Nitric Oxide Synthetase Expression. Current Medicinal Chemistry, 2014 June , 2014;21（17）：2012-2022//.(21):2012-2022.
• Chiang Shuo-Ju, Daimon Masao, Wang Li-Hsuan, Hung Ming-Jui, Chang Nen-Chung, Lin Hsiu-Chen(2014).Association between mitral valve prolapse and open-angle glaucoma. Heart. December 11, 2014 as 10.1136/heartjnl-2014-306198.():-.
• Kao Yung-Ta, Wang Sen-Te, Shih Chun-Ming, Lin Fen-Yen, Tsao Nai-Wen, Chiang Kuang-Hsing, Chang Nen-Chung(2014).Arterial stiffness index and coronary artery plaque in patients with subclinical coronary atherosclerosis. Acta Cardiologica Sinica.(accept):-.
• Shih Chun-Ming, Chen Yung-Hsiang, Lin Yi-Wen, Tsao Nai-Wen, Wu Shinn-Chih, Yung-Ta Kao,Kuang-Hsing Chiang, Chi-Yuan Li, Nen-Chung Chang(2014).MK-0626, A Dipeptidyl Peptidase-4 Inhibitor, Improves Neovascularization by Increasing Both the Number of Circulating Endothelial Progenitor Cells and Endothelial Nitric Oxide Synthetase Expression. Current Medicinal Chemistry, June 1, 2014, 21（17）, 2012-2022//.(21):2012-2022.
• Chang Nen-Chung, Lin Chor-Ming, Hsu Cheng-Chen, Liu Jung-Sheng, Tsui Leo, Chen Chien-Yuan, Fong Tsorng-Harn(2013).Okadaic Acid, a Bioactive Fatty Acid from Halichondria okadai, Stimulates Lipolysis in Rat Adipocytes:The Pivotal Role of Perilipin Translocation. Evidence-Based Complementary and Alternative Medicine.2013,Volume 2013, Article ID 545739, p1-10; On line: http://dx.doi.org/10.1155/2013/545739.//.(2013):1-10.
• Lee Tsung-Ming, Lin Shinn-Zong, Chang Nen-Chung(2013).Both PKA and Epac Pathways Mediate N-Acetylcysteine-Induced Connexin43 Preservation in Rats with myocarial infarction. Plos One. August 2013; 8(8): e71878//.(8):-e71878.
• Lee TM, Lin SZ, Chang NC(2013).Membrane ERα attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats. J Mol Med (Berl).(92):43-51.
• Hung Ming-Jui, Hsu Kuang-Hung, Hu Wei-Syun, Chang Nen-Chung, Hung Ming-Yow(2013).C-reactive protein for predicting prognosis and its gender-specific associations with diabetes mellitus and hypertension in the development of coronary artery spasm. PloS one 2013; 8(10):e77655.(8):e77655-e77655.
• Lee Tsung-Ming, Chen Chien-Chang, Chang Nen-Chung(2012).Cardiac sympathetic hyperinnervation in deoxycorticosterone acetate-salt hypertensive rats. Clinical Science.2012 Jun.,2012; 123(7):445-457//.(123):445-457.
• Tsao Nai-Wen, Shih Chun-Ming, Chang Nen-Chung, Lin Feng-Yen, Huang Chun-Yao(2012).Extracorporeal membrane oxygenation–assisted primary percutaneous coronary intervention may improve survival of patients with acute myocardial infarction complicated by profound cardiogenic shock. Journal of Critical Care 2012 Oct., 27(5): 530.e1-e11//.(27):530.e1-e11.
• Lee Tsung-Ming, Chen Chien-Chang, Chung Tun-Hui, Chang Nen-Chung(2012).Effect of sildenafil on ventricular arrhythmias in post-infarcted rat hearts. Eur J Pharmacol. 2012 Sept., 2012; 690(1-3):124-132//.(690):124-132.
• Huang Chun-Yao, Shih Chun-ming, Tsao Nai-wen, Lin Yi-Wen, Huang Po-Hsun, Wu Shinn-Chih,Lee Ai-Wei, Kao Yun-Ta, Chang Nen-Chung(2012).Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells. Brit J Pharmacol., Dec. 2012, 2012; 167(7):1506-1519//.(167):1506-1519.
• Huang Chun-Yao, Lin Feng-Yen, Shih Chun-Ming, Au Heng-Kien, Chang Yu-Jia, Chang Nen-Chung(2012).Moderate to high concentrations of high-density lipoprotein from healthy subjects paradoxically impair human endothelial progenitor cells and related angiogenesis by activating rho-associated kinase pathways. Arterioscler Thromb Vasc Biol.,2012, Oct., 2012;32(10):2405-17//.(32):2405-17.
• Huang Chun-Yao, Shih Chun-Ming, Tsao Nai-Wen, Chen Yung-Hsiang, Li Chi-Yuan, Chang Yu-Jia, Chang Nen-Chung(2012).GroEL1, from Chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37(AUF1) in endothelial cells and hypercholesterolemic rabbit. PLoS One 2012 Aug., 2012; 7(8): e42808, DOI: 10.1371/journal.pone.0042808//.(7):-e42808.
• Kao Yung-Ta, Shih Chun-Ming, Lin Feng-Yen, Tsao Nai-Wen, Chang Nen-Chung, Huang Chun-Yao(2012).An endoluminal aortic prosthesis infection presenting as pneumoaorta and aortoduodenal fistula. World J Gastroenterol 2012 October 7, 18(37): 5309-5311//.(18):5309-5311.
• Hung Ming-Jui, Hsu Kuang-Hung, Chang Nen-Chung, Tsimikas Sotirios, Hung Ming-Yow(2015).Prevalence of coronary artery spasm after stent placement and its association with inflammation. International Journal of Cardiology, 2015, 179.(179):252-255.