Ray-Jade Chen, MD MSc

Gastrointestinal Surgery

SPECIALTY/PRACTICE AREAS：
• Hepato-Biliary-Pancreatic surgery
• Acute care surgery
• Trauma epidemiology
• Critical care medicine
• Hospital management
• Medical informatics
LANGUAGES SPOKEN：
• English
• Chinese

 

PROFESSIONAL EDUCATION：

• Graduate Institute of Biomedical Informatics, Taipei Medical University, Taiwan
• School of Medicne, Taipei Medical University, Taiwan

   

ADMINSTRATIVE APPOINTMENTS：

• Vice Director of Surgery
• Chief of General Surgery
• Chief of Comprehensive weight Management Center
• Associate Professor of Taipei Medical University

   

PUBLICATIONS：

• Chen YP, Tsai CW, Shen CY, Day CH, Yeh YL, Chen RJ, Ho TJ, Padma VV, Kuo WW, Huang CY. Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in cardiomyoblasts. J Nutr Biochem. 2016 May;31:137-49.
• Tai CJ, Huang MT, Wu CH, Wang CK, Tai CJ, Chang CC, Hsieh CI, Chang YJ, Wu CJ, Kuo LJ, Wei PL, Chen RJ, Chiou HY. Combination of Two Targeted Medications (Bevacizumab Plus Cetuximab) Improve the Therapeutic Response of Pancreatic Carcinoma. Medicine (Baltimore). 2016 Apr;95(15):e3259.
• Chen MC, Lee NH, Hsu HH, Ho TJ, Tu CC, Chen RJ, Lin YM, Viswanadha VP, Kuo WW, Huang CY. Inhibition of NF-κB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38. Environ Toxicol. 2016 Apr 5.
• Chang YM, Chang HH, Kuo WW, Lin HJ, Yeh YL, Padma Viswanadha V, Tsai CC, Chen RJ, Chang HN, Huang CY. Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart. Int J Mol Sci. 2016 Mar 29;17(4):466.
• Tai CJ, Wang H, Wang CK, Tai CJ, Huang MT, Wu CH, Chen RJ, Kuo LJ, Wei PL, Chang YJ, Chang CC, Chiou HY, Wu CJ. Bevacizumab and cetuximab with conventional chemotherapy reduced pancreatic tumor weight in mouse pancreatic cancer xenografts. Clin Exp Med. 2016 Mar 19
• Tsai CT, Chang YM, Lin SL, Chen YS, Yeh YL, Padma VV, Tsai CC, Chen RJ, Ho TJ, Huang CY. Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts. J Med Food. 2016 Mar;19(3):300-9.
• Yeh YL, Tsai HI, Cheng SM, Pai P, Ho TJ, Chen RJ, Lai CH, Huang PJ, Padma VV, Huang CY. Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts. Am J Chin Med. 2016;44(1):77-86.
• Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR. Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats. Transl Res. 2016 Apr;170:57-72.
• Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR. Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats. Transl Res. 2015 Dec 17. pii: S1931-5244(15)00425-9. doi: 10.1016/j.trsl.2015.12.002. [Epub ahead of print]
• Jean SS, Lee WS, Yu KW, Liao CH, Hsu CW, Chang FY, Ko WC, Chen RJ, Wu JJ, Chen YH, Chen YS, Liu JW, Lu MC, Lam , Liu CY, Hsueh PR. Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). J Microbiol Immunol Infect. 2015 Jan 10. pii: S1684-1182(15)00021-3. doi: 10.1016/j.jmii.2014.12.008. [Epub ahead of print]
• Jean SS, Lee WS, Bai KJ, Lam C, Hsu CW, Yu KW, Liao CH, Chang FY, Ko WC, Wu JJ, Chen YH, Chen YS, Liu JW, Lu MC, Liu CY, Chen RJ, Hsueh PR. Relationship between the distribution of cefepime minimum inhibitory concentrations and detection of extended-spectrum β-lactamase production among clinically important Enterobacteriaceae isolates obtained from patients in intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2007. J Microbiol Immunol Infect. 2015;48(1):85-91.
• Ting WJ, Kuo WW, Hsieh DJ, Yeh YL, Day CH, Chen YH, Chen RJ, Padma VV, Chen YH, Huang CY. Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression. Int J Mol Sci. 2015;16(10):25881-96.
• Liao PH, Hsieh DJ, Kuo CH, Day CH, Shen CY, Lai CH, Chen RJ, Padma VV, Kuo WW, Huang CY. Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts. 2015;6(34):35383-94.
• Luo CC, Chien WK, Huang CS, Huang HC, Lam C, Hsu CW, Chen RJ, Cheng KF. National trends in therapeutic approaches and outcomes for pediatric appendicitis: a Taiwanese nationwide cohort study. Pediatr Surg Int. 2015;31(7):647-51.
• Fu CY, Huang HC, Chen RJ, Tsuo HC, Tung HJ. Implementation of the acute care surgery model provides benefits in the surgical treatment of the acute appendicitis. Am J Surg. 2014;208(5):794-9.
• Lin BC, Fang JF, Chen RJ, Wong YC, Hsu YP. Surgical management and outcome of blunt major liver injuries: Experience of damage control laparotomy with perihepatic packing in one trauma centre. Injury. 2014;45(1):122-7.
• Chang HC, Chiu YW, Lin YM, Chen RJ, Lin JA, Tsai FJ, Tsai CH, Kuo YC, Liu JY, Huang CY. Herbal supplement attenuation of cardiac fibrosis in rats with CCl₄-induced liver cirrhosis. Chin J Physiol. 2014 ;57(1):41-7.
• Lam C, Kuan CF, Miser J, Hsieh KY, Fang YA, Li YC, Hsu CW, Chen RJ, Chen CI. Emergency department utilization can indicate early diagnosis of digestive tract cancers: A population-based study in Taiwan. Comput Methods Programs Biomed. 2014;115(3):103-9.
• Hu WS, Lin YM, Ho TJ, Chen RJ, Li YH, Tsai FJ, Tsai CH, Day CH, Chen TS, Huang CY. Genistein Suppresses the Isoproterenol-Treated H9c2 Cardiomyoblast Cell Apoptosis Associated with P-38, Erk1/2, JNK, and NF κ B Signaling Protein Activation. Am J Chin Med. 2013;41(5):1125-36.
• Fu CY, Hsieh CH, Wu SC, Chen RJ, Wang YC, Shih CH, Huang HC, Huang JC, Tsuo HC, Tung HJ. Anterior-posterior Compression Pelvic Fracture Increases the Probability of Requirement of Bilateral Embolization. Am J Emerg Med. 2013;31(1):42-9.
• Lu CW, Liu LC, Hsieh YC, Yang LH, Chen RJ, Hsieh CH. Increased admission serum estradiol level is correlated with high mortality in patients with severe acute pancreatitis. J Gastroenterol. 2013;48(3):374-81.
• Chiu YH, Chen JD, Wang SH, Tiu CM, How CK, Lai JI, Chou YH, Lam C, Chen RJ. Whether intravenous contrast is necessary for CT diagnosis of acute appendicitis in adult ED patients? Acad Radiol. 2013;20(1):73-8.
• Chang YM, Tsai CT, Wang CC, Chen YS, Lin YM, Kuo CH, Tzang BS, Chen RJ, Tsai FJ, Huang CY. Alpinate oxyphyllae fructus (Alpinia Oxyphylla Miq) extracts inhibit angiotensin-II induced cardiac apoptosis in H9c2 cardiomyoblast cells. Biosci Biotechnol Biochem. 2013;77(2):229-34.
• Chiu YH, Hou SK, How CK, Li LH, Kao WF, Yang CC, Chou SL, Shiau YT, Lam C, Chen RJ. Influence of a 100 km ultra-marathon on hepatitis B carrier runners. Int J Sports Med. 2013;34(9):841-5.
• Abdelfadil E, Cheng YH, Bau DT, Ting WJ, Chen LM, Hsu HH, Lin YM, Chen RJ, Tsai FJ, Tsai CH, Huang C. Thymoquinone induces apoptosis in oral cancer cells through p38β inhibition. Am J Chin Med. 2013;41(3):683-96.
• Tu CC, Kumar VB, Day CH, Kuo WW, Yeh SP, Chen RJ, Liao CR, Chen HY, Tsai FJ, Wu WJ, Huang CY. Estrogen receptor α (ESR1) over-expression mediated apoptosis in Hep3B cells by binding with SP1 proteins. J Mol Endocrinol. 2013;51(1):203-12.
• Fu CY, Wu SC, Chen RJ, Huang JC. Blunt Pancreatic Head Hematoma as an Infrequent Cause of Delayed Obstructive Jaundice. J Emerg Med. 2012;42(2):e27-9.
• Wu SC , Fu CY, Lin HH, Chen RJ, Hsieh CH, Wang YC, Yeh CC, Huang HC, Huang JC, Chang YJ. Late initiation of continuous veno-venous hemofiltration therapy is associated with a lower survival rate in surgical critically ill patients with postoperative acute kidney injury. Am Surg. 2012;78(2):235-42.
• Fu CY, Wang YC, Wu SC, Chen RJ, Hsieh CH, Huang HC, Huang JC, Lu CW, Huang YC. Angioembolization provides benefits in patients with concomitant unstable pelvic fracture and unstable hemodynamics. Am J Emerg Med. 2012;30(1):207-13.
• Fu CY, Wang YC, Wu SC, Chen YF, Chen RJ, Hsieh CH, Huang HC, Huang JC, Lu CW, Huang YC. Higher glucose on admission is associated with need for angioembolization in stable pelvic fracture. Am J Emerg Med. 2012;30(1):26-31.
• Huang YC, Wu SC, Fu CY, Chen YF, Chen RJ, Hsieh CH, Wang YC, Huang HC, Huang JC, Lu CW. Tomographic Findings are not Always Predictive of Failed Nonoperative Management in Blunt Hepatic Injury. Am J Surg. 2012;203(4):448-53.
• Fu CY, Hsieh CH, Shih CH, Wang YC, Chen RJ, Huang HC, Huang JC, Wu SC, Lin C. The Effects of Repeat laparoscopic Surgery on the Treatment of Complications Resulting from Laparoscopic Surgery. Am Surg. 2012;78(9):926-32.
• Fu CY, Hsieh CH, Shih CH, Wang YC, Chen RJ, Huang HC, Huang JC, Wu SC, Tsuo HC, Tung HJ. Selective Computed Tomography and Angioembolization Provide Benefits in the Management of Patients with Concomitant Unstable Hemodynamics and Negative Sonography Results. World J Surg. 2012;36(4):819-25.
• Hsu HH, Liu CJ, Shen CY, Chen YJ, Chen LM, Kuo WH, Lin YM, Chen RJ, Tsai CH, Tsai FJ, Huang CY. p38α MAPK mediates 17β-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells. J Cell Physiol. 2012;227(11):3648-60.
• Huang HC, Fu CY, Hsieh CH, Wang YC, Wu SC, Chen RJ, Huang JC. Lodox/Statscan Facilitates the Early Detection of Commonly Overlooked Extracranial Injuries in Patients with Traumatic Brain Injury. Eur J Trauma Emerg Surg. 2012;38(3):319-26.
• Wu SC, Fu CY, Chen RJ, Chen YF, Wang YC, Chung PK, Yu SF, Tung CC, Lee KH. Higher incidence of major complications after splenic embolization for blunt splenic injuries in elderly patients. Am J Emerg Med. 2011;29(2):135-40.
• Wu SC, Wang YC, Fu CY, Chen RJ, Huang HC, Huang JC, Lu CW, Hsieh CH, Lin CY. Laparoscopic appendectomy provides better outcomes than open appendectomy in elderly patients. Am Surg. 2011 ;77(4):466-70.
• Fu CY, Wang YC, Hsieh CH, Chen RJ. LodoxStatscan provides benefits in evaluation of gunshot injuries. Am J Emerg Med. 2011;29(7):823-7.
• Kuo CL, Chiu YH, How CK, Wang JB, Kao HL, Lam C, Chen RJ. Airway compromise caused by the spontaneous thyroid hemorrhage. Resuscitation. 2011;82(9):1249-50.
  
  Case Report：
• Jean SS, Lee WS, Bai KJ, Lam C, Hsu CW, Chen RJ, Hsueh PR. Leclercia adecarboxylata bacteremia in a patient with long-term use of nonsteroidal anti-inflammatory drugs. J Microbiol Immunol Infect. 2013 Oct 30. pii: S1684-1182(13)00171-0. doi: 10.1016/j.jmii.2013.09.004. [Epub ahead of print]
• Fu CY, Shih CH, Chang PY, Hsiao CH, Wang YC, Chen RJ. Conservative treatment of concomitant extraperitoneal bladder rupture and intrabladder blood clot formation: Case report of application of ureteral catheterization. Can Urol Assoc J. 2012;6(6):E256-8.