Hsiung-Fei Chien, MD

Aesthetic Medical Center

• General plastic surgery
• Breast reconstruction
• Breast aesthetics
• Vaser liposuction and body sculpturing

• English
• Chinese



  • Ph.D. College of Medicine National Taiwan University
  • EMBA. College of Management National Taiwan University
  • M.D. College of Medicine National Taiwan University



  • Plastic Surgery Resident of National Taiwan University Hospital
  • Plastic Surgeon of National Cheng Kung University Hospital
  • Plastic Surgeon of National Taiwan University Hospital
  • Associate Professor ,Department of Surgery, School of Medicine, National Taiwan University Hospital



  • Chang CW, Tai HC, Cheng NC, Li WT, Lai HS, Chien HF. Risk factors of complications following immediate tissue expander based breast reconstructions in Taiwanese population. Journal of the Formosan Medical Association, 2016 Feb 29. pii: S0929-6646(16)00053-X. doi: 10.1016/j.jfma.2016.01.012. [Epub ahead of print] (corresponding author)
  • Chang CW, Tai HC, Cheng NC, Li WT, Lai HS, Chien HF. Risk factors of complications following immediate tissue expander based breast reconstructions in Taiwanese population. Journal of the Formosan Medical Association, 2016 Feb 29. pii: S0929-6646(16)00053-X. doi: 10.1016/j.jfma.2016.01.012. [Epub ahead of print] (corresponding author)
  • Chen CH, Sun HY, Chien HF, Lai HS, Chou NK: Blastocystis hominis infection in a post-cardiotomy patient on extracorporeal membrane oxygenation support: A case report and literature review. Int J Surg Case Rep 2014;5:637-639.
  • Liu TJ, Ko AT, Tang YB, Lai HS, Chien HF, Hsieh TM. Clinical Application of Different Surgical Navigation Systems in Complex Craniomaxillofacial Surgery: The Use of Multisurface 3-Dimensional Images and a 2-Plane Reference System. Ann Plast Surg. 2016 Apr; 76(4):411-9. doi: 10.1097/SAP.0000000000000429.
  • Liu MC, Kuo KT, Chien HF, Tsai YL, Liaw SJ. New Aspects of RpoE in Uropathogenic Proteus mirabilis. Infect Immun. 2015 Mar;83(3):966-77.
  • Johansson G, Peng PC, Huang PY, Chien HF, Hua KT, Kuo ML, Chen CT, Lee MJ. Soluble AXL: a possible circulating biomarker for neurofibromatosis type 1 related tumor burden. PLoS One. 2014 Dec 31;9(12):e115916.
  • Chen SH, Chen HC, Horng SY, Tai HC, Hsieh JH, Yeong EK, Cheng NC, Hsieh TM, Chien HF, Tang YB: Reconstruction for osteoradionecrosis of the mandible: superiority of free iliac bone flap to fibula flap in postoperative infection and healing. Ann Plast Surg 2014;73 Suppl 1:S18-S26
  • Min-Cheng Wang, Chien HF, Yi-Lin Tsai, Ming-Che Liu and Shwu-Jen Liaw The RNA chaperone Hfq is involved in stress tolerance and virulence in uropathogenic Proteus mirabilis. PLoS ONE 2014;9:e85626.
  • C Chen CH, Young TH, Huang CH, Chang HH, Chen CL, Chien HF, Chen JS, Lai HS, Cheng NC: Patient-Centered Wound Teleconsultation for Cutaneous Wounds: A Feasibility Study. Ann Plast Surg 2014; 72:220-224.
  • Chen CC, Chien HF, Chen CL: Compression Neuropathy of the Ulnar Digital Nerves in the Thumbs of a Massage Therapist. Ann Plast Surg 2014;72:649-651.
  • Yang YT, Chien HF, Chang PH, Chen YC, Jay M, Tsai T, Chen CT: Photodynamic inactivation of chlorin e6-loaded CTAB-liposomes against Candida albicans. Lasers Surg Med 2013;45:175-185.
  • Chien HF, Chen CP, Chen YC, Chang PH, Tsai T, Chen CT: The Use of Chitosan to Enhance Photodynamic Inactivation against Candida albicans and Its Drug-Resistant Clinical Isolates. Int J Mol Sci 2013;14:7445-7456.
  • Lee YH, Chang JJ, Chien CT, Yang MC, Chien HF: Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats. Exp Diabetes Res 2012;2012:504693. (co-corresponding author)
  • Liu MC, Lin SB, Chien HF, Wang WB, Yuan YH, Hsueh PR, Liaw SJ: 10’(Z),13’(E)-Heptadecadienylhydroquinone Inhibits Swarming and Virulence Factors and Increases Polymyxin B Susceptibility in Proteus mirabilis. PLoS ONE 2012;7:e45563 (co-first author)
  • Roan TL, Horng SY, Hsieh JH, Tai HC, Chien HF, Tang YB: New modified free chimeric fibular flap design for head and neck reconstruction. Head Neck 2012 Jun 19. doi: 10.1002/hed.23049. [Epub ahead of print].
  • Kuo, Y.S., H.F. Chien, W. Lu Plectranthus amboinicus and Centella asiatica cream in the treatment of diabetic foot ulcers. Evidence-Based Complementary and Alternative Medicine, 2012 (corresponding author)
  • Yang, Y. T., C. T. Chen, H. F. Chien, T. Tsai. Cellular photodynamic toxicity of hematoporphyrin in various nanocarrier systems. Current Nanoscience 2011; 7 , 850-855 (corresponding author)
  • Wang SH, Liang CJ, Wu JC, Huang JJ, Chien HF, Tsai JS, Yen YS, Tseng YC, Lue JH, Chen YL Pigment epithelium-derived factor reduces the PDGF-induced migration and proliferation of human aortic smooth muscle cells through PPAR activation. Int J Biochem Cell Biol. 2011
  • Wang, S. H., Liang,C.J., Weng, Y. W., Chen, Y. H., Hsu, H. Y., Chien, H. F., Tsai, J. S. Tseng, Y. C., Li, C. Y., Chen, Y. L. Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo. J. Cellular Physiology 2011
  • Tsai, T., H. F. Chien, T. H. Wang, C. T. Huang, Y. B. Ker, and C. T. Chen. 2011. Chitosan augments photodynamic inactivation of gram-positive and gram-negative bacteria. Antimicrob.Agents Chemother. 55:1883-1890.
  • Ko, Y. C., C. L. Chang, H. F. Chien, C. H. Wu, and L. I. Lin. 2011. Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells. Cancer Lett. 309:46-53.
  • Roan, T. L., C. K. Chen, S. Y. Horng, J. H. Hsieh, H. C. Tai, M. H. Hsieh, H. F. Chien, and Y. B. Tang. 2011. Surgical technique innovation for the excision of subungual glomus tumors. Dermatol.Surg. 37:259-262.
  • Chen, C. K., H. C. Tai, H. F. Chien, and Y. B. Chen. 2010. Various modifications to internal mammary vessel anastomosis in breast reconstruction with deep inferior epigastric perforator flap. J.Reconstr.Microsurg. 26:219-223.
  • Ji, H. T., L. T. Chien, Y. H. Lin, H. F. Chien, and C. T. Chen. 2010. 5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase. Mol.Cancer 9:91.
  • Jiang-Shieh, Y. F., H. F. Chien, C. Y. Chang, T. S. Wei, M. M. Chiu, H. M. Chen, and C. H. Wu. 2010. Distribution and expression of CD200 in the rat respiratory system under normal and endotoxin-induced pathological conditions. J.Anat. 216:407-416.
  • Wu, W. H., S. H. Wang, I. I. Kuan, Y. S. Kao, P. J. Wu, C. J. Liang, H. F. Chien, C. H. Kao, C. J. Huang, and Y. L. Chen. 2010. Sesamin attenuates intercellular cell adhesion molecule-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice. Mol.Nutr.Food Res. 54:1340-1350.
  • Lin, S. J., F. Y. Hsieh, Y. H. Chen, C. C. Lin, I. I. Kuan, S. H. Wang, C. C. Wu, H. F. Chien, F. Y. Lin, and Y. L. Chen. 2009. Atorvastatin induces thrombomodulin expression in the aorta of cholesterol-fed rabbits and in TNFalpha-treated human aortic endothelial cells. Histol.Histopathol. 24:1147-1159.
  • Tsai, T., Y. T. Yang, T. H. Wang, H. F. Chien, and C. T. Chen. 2009. Improved photodynamic inactivation of gram-positive bacteria using hematoporphyrin encapsulated in liposomes and micelles. Lasers Surg.Med. 41:316-322.
  • Tsai, M. K., H. F. Chien, M. C. Tzeng, and P. H. Lee. 2009. Effects of B cell depletion on T cell allogeneic immune responses: a strategy to reduce allogeneic sensitization. Transpl.Immunol. 21:215-220.
  • Ko, Y. C., H. F. Chien, Y. F. Jiang-Shieh, C. Y. Chang, M. H. Pai, J. P. Huang, H. M. Chen, and C. H. Wu. 2009. Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions. J.Anat. 214:183-195.
  • Ou,D.L.; Chien, H. F.; Chen,C.L.; Lin,T.C.; Lin,L.I. Role of Twist in head and neck carcinoma with lymph node metastasis. Anticancer Res. 28(2B) 1355-9, 2008
  • Chien,HF,Liao,YH Chen,CT. Topical 5-aminolevulinic acid photodynamic therapy for warts Lasers Surg.Med. 39(S19) 57, 2007
  • Chang ML, Wu CH, Chien HF, Jiang-Shieh,YF, Shieh,JY, Wen,CY. Microglia/macrophages responses to kainate-induced injury in the rat retina. Neuroscience research 54: 202-212, 2006 (SCI)
  • Chiang HY*, Chien HF* , Shen HH, Yang JD, Chen YH, Chen JH, Jsieh ST. Reinnervation of muscular targets by nerve regeneration through polycaprolactone conduits. Journal of neuropathology and experimental neurology 64, 1-12, 2005 *equal contribution (SCI)
  • Jiang-Shieh, YF, Yeh KY, Wei IH, Chang CY, Chien HF, Tsai RY, Chang M, Lee AW, Pai MH, Wu CH. Responses of microglia in vitro to gram-positive bacterial component, lipoteichoic acid. Journal of Neuroscience Research 82 :515-524, 2005(SCI)
  • Cheng NC, Chen Tang YB, Chien HF. Myxoid solitary fibrous tumor of the axilla. British Journal of Plastic Surgery 59: 86-89, 2006 (corresponding author) (SCI)
  • Tsai,JC; Wu,C.L.; Chien,H.F.; Chen,C.T.Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction. Lasers Surg. Med. 36:398-408, 2005 (SCI)
  • Jiang-Shieh YF, Wu CH, Chien HF, Wei,IH, Chang ML, Shieh JY, Wen CY. Reactive changes of interstitial glia and pinealocytes in the rat pineal gland challenged with cell wall components from gram-positive and -negative bacteria. J. Pineal Res. 38: 17-26, 2005(SCI)
  • Chien HF, Yeh KY, Jiang-Shieh YF, Wei I, Chang CY, Chang ML, Wu CH. Signal transduction pathways of nitric oxide release in primary microglial culture challenged with gram positive bacterial constituent, lipoteichoic acid. Neuroscience, 133: 423-436, 2005(SCI)
  • Tsai MK, Ho HN, Chien HF, Tseng MC, Chen CH, Lee PH. Multiple negative feedbacks on CD152 expression in allograft tolerance. Transplantation, 79: 174-181, 2005(SCI)
  • Chiang HY, Chen CT, Chien HF, Hsieh ST. Skin denervation, neuropathology, neuropathic pain in a laser-induced focal neuropathy. Neurobiology of disease18: 40-53, 2005(SCI)
  • Tsai MK, Ho HN, Chien HF, Ou-Yang Pu, Lee CJ, Lee PH. The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: a crosscheck hypothesis. Transplantation 77(1): 48-54, 2004 (SCI)
  • Chang CY, Chien HF, Jiangshieh YF, Wu CH. Microglia in the olfactory bulb of rats during postnatal development and olfactory nerve injury with zinc sulfate: a lectin labeling and ultrastructural study. Neuroscience research 45: 325-333, 2003 (SCI)
  • Chien HF, Tseng TJ, Lin WM, Yang CC, Chang YC, Chen RC, Hsieh ST . Quantitative pathology of cutaneous nerve terminal degeneration in the human skin. Acta Neuropathologica,102: 462-466, 2001 (SCI)
  • Chien HF, Wu CH, Wen CY, Shieh JY. Blood supply of lower intraorbital fat—relevance for orbital floor fracture and its complication of anaerobic cellulitis. Journal of the Formosan Medical Association,100: 192-197, 2001 (SCI)
  • Chien HF . Ph.D. thesis: The roles of macrophages in the degenerating peripheral nerves of rodents, 2001
  • Wu CH, Chien HF, Chang CY, Chen, SH, Huang YS. Response of amoeboid and differentiating ramified microglia to glucocorticoids in postnatal rats: a lectin histochemical and ultrastructural study. Neuroscience research 40: 235-244, 2001 (SCI)
  • Lin S, Lu CC, Chien HF, Hsu SM. An on-line quantitative immunoassay system based on a quartz crystal microbalance. Journal of Immunological Methods 239: 121-124, 2000 (SCI)
  • Chien CT, Chien HF, Cheng YJ, Chen CF, Hsu SM. Renal afferent signaling diuretic response is impaired in streptozotocin-induced diabetic rats. Kidney International 57: 203-214,2000 (SCI)
  • Wang CH, Horng SY, Chien HF, Chen MT.Psoas muscle abscess—diagnosis and approaches of treatment. The Journal of Plastic and Reconstructive Surgical Association R.O.C 9:235-245, 2000
  • Chien HF. Discussion in “Deep sternal wound infection after median sternotomy” by Perng CK, Chen HC, Chen HS, Chen HT The Journal of Plastic and Reconstructive Surgical Association R. O. C. 8: 233-244, 1999
  • Chiang HY, Huang IT, Chen WP, Chien HF, Shun CT, Chang YC, Hsieh ST: Regional difference in epidermal thinning after skin denervation. Experimental Neurology 154: 137-145, 1998 (SCI)
  • Ali Z, Ringkamp M, Hartke TV, Chien HF, FlavahanNA, Campbell JN, Meyer RA. Uninjured c-fiber nociceptors develop spontaneous alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J of Neurophysiology 81:455-466, 1999 (SCI)
  • Ransohoff RM, Tani M, Glabinski AR, Chernosky A, Krivacic K, Peterson JW, Chien HF, Trapp BD: Chemokines and chemokine receptors in model neurological pathologies: molecular and immunocytochemical approaches. Methods in Enzymology 287:319-348, 1997 (SCI)
  • Wu CH. Chien HF. Chang CY. Ling EA. Heterogeneity of antigen expression and lectin labeling on microglial cells in the olfactory bulb of adult rats. Neuroscience Research. 28(1): 67-75, 1997 (SCI)
  • Li YB, Hsieh ST, Chien HF, Zhang XR, McArthur JC, Griffin JW. Sensory and motor denervation influence epidermal thickness in rat foot glabrous skin. Experimental Neurology. 147:452-462, 1997 (SCI)
  • Sun,T.B.; Chien,H.F.; Huang,S.F.; Shih,T.T.; Chen,M.T.Malignant chondroid syringoma J.Formos.Med.Assoc. 95:575-578,1996(SCI) (corresponding author)
  • Chien,H.F.; Chu,S.H. Simultaneous Bentall's procedure and sternal turnover in a patient with Marfan syndrome J.Cardiovasc.Surg. 36: 559-562, 1995(SCI)                                                                                                                                                2017.09.25