Shyr-Yi Lin, M.D., Ph.D.


• GI tract
• GB
• liver disorder

• English
• Chinese



  • MD, School of Medicine, TMU
  • PhD, Graduate Institute of Medicine, TMU
  • MBA, College of Management, NTU



  • Chief, Division of Endoscopy, TMUH
  • Chief, Department of Primary Care Medicine, TMUH
  • Vice Superintendent, TMUH
  • Chairman, School of Medicine, TMU
  • Vice Dear, College of Medicine, TMU
  • Dear, R and D Office, TMU



  • Wu GC, Lin SY, Liang HJ, Hou WC(2018).135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice. J. Agric. Food Chem.(66):645-652.
  • Lin SF, Jiang PL, Tsai JS, Huang YY, Lin SY, Lin JH, Liu DZ(2018).Surface assembly of poly(I:C) on polyethyleneimine-modified gelatin nanoparticles as immunostimulatory carriers for mucosal antigen delivery. J Biomed Mater Res B Part B.
  • Su CY, Chen M, Chen LC, Ho YS, Ho HO, Lin SY,Chuang KH, Sheu MT(2018).Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors. Drug Delivery.(25):1066-1079.
  • Chang CC, Chang YS, Wang SH, Lin SY, Chen YH, Chen JH(2017).Primary Sjogren's syndrome and the risk of acute pancreatitis: a nationwide cohort study. BMJ Open.(11):e01480-e01480.
  • Chang WH, Niu DM, Lu CY, Lin SY*, Liu TC, Chang JG(2017).Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease. PLOS ONE.(12):1-17.
  • Lu YL, Lin SY, Fang SU, Hsieh YY, Chen CR, Wen C, Chang CI, Hou WC(2017).Hot-Water Extracts from Roots of Vitis thunbergii var. taiwaniana and Identified ε-Viniferin Improve Obesity in High-Fat Diet-Induced Mice. Journal of Agricultural and Food Chemistry.(65):2521-2529.
  • Lin YS, Han CH, Lin SY*, Hou WC(2016). (2016, Aug). Synthesized peptides from yam dioscorin hydrolysis in silico exhibit dipeptidyl peptidase-IV inhibitory activities and oral glucose tolerance improvements in normal mice.. Journal of Agricultural and Food Chemistry, (64):6451-6458.
  • Liu YH, Lin YS, Huang YW, Fang SU, Lin SY*, Hou WC(2016). (2016, May). Protective Effects of Minor Components of Curcuminoids on Hydrogen Peroxide-Treated Human HaCaT Keratinocytes.. Journal of Agricultural and Food Chemistry, (64):3598-3608.
  • Chang CC, Tsai YH, Liu Y, Lin SY*, Liang YC (2015, Oct). Calcium-containing crystals enhance receptor activator of nuclear factor κB ligand/macrophage colony-stimulating factor-mediated osteoclastogenesis via extracellular-signal-regulated kinase and p38 pathways.. Rheumatology, 54(10):1913-22.
  • Lin SY, Huang GC, Hsieh YY, Lin YS, Han CH, Wen CL, Chang CI, Hou WC (2015, Oct). Vitis thunbergii var. taiwaniana Extracts and Purified Compounds Ameliorate Obesity in High-Fat Diet-Induced Obese Mice.. J. Agric. Food Chem., (63):9286-9294.
  • Etienne Simon-Loriere, Ren-Jye Lin,Sita Mint Kalayanarooj, Ampaiwan Chuansumrit, Isabelle Casademont, Shyr-Yi Lin, Han-Pang Yu, Worachart Lert-itthiporn, Wathanee Chaiyaratana,Nattaya Tangthawornchaikul,Kanchana Tangnararatchakit, Sirijitt Vasanawathana,Bi-Lan Chang,Prapat Suriyaphol, Sutee Yoksan,Prida Malasit,Philipe Despres, Richard Paul, Yi-Ling Lin, and Anavaj Sakuntabhai1 (2015, Jul). High Anti–Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue. Journal of Infectious Diseases, 2015, July 8.
  • Huang YW, Wang TC, Yang SS, Lin SY, Fu SC, Hu JT, Liu CJ, Kao JH, Chen DS (2015, Jul). Increased risk of hepatocellular carcinoma in chronic hepatitis C patients with new onset diabetes: A nationwide cohort study.. Alimentary Pharmacology & Therapeutics, 42(7):902-911.
  • Suk FM, Lin SY, Lin RJ, Hsine YH, Liao YJ, Fang SU, and Liang YC (2015, Jul). Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression. Oncotarget, July 17, 2015.
  • Yuh-Hwa Liu, Yin-Shiou Lin3, Kuan-Ling Lin, Yeh-Lin Lu, Chao-Hsiang Chen, Mei-Yin Chien, Huey-Fang Shang, Shyr-Yi Lin* and Wen-Chi Hou (2015, Jul). Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo. Botanical Studies , 56:17.
  • Yin Shiou Lin · Wen Chung Wu · Shyr Yi Lin* · Wen Chi Hou (2015, Jun). Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways. Amino Acids, 47:617–625.
  • Chang CC, Chen LY, Yang KH, Chen QY, Liang YC, Lin SY*, Liu YC (2015, May). Surface-enhanced Raman scattering on a silver film-modified Au nanoparticle-decorated SiO2 mask array. . RSC Advances., (5):66096-66103.
  • Yuarn-Jang Lee, Jen-Zon Chen, Hsiu-Chen Lin, Hsin-Yi Liu, Shyr-Yi Lin, Hsien-Ho Lin, Chi-Tai Fang and Po-Ren Hsueh (2015, Apr). Impact of active screening for methicillin-resistant Staphylococcus aureus (MRSA) and decolonization on MRSA infections, mortality and medical cost: a quasi-experimental study in surgical intensive care unit. Critical Care , 19:143.
  • Shen-Liang Shih, Yin-Shiou Lin, Shyr-Yi Lin* and Wen-Chi Hou (2015, Jan). Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats. Botanical Studies , 56:4.
  • Lin RJ, Chu JS, Chien HL, Tseng CH, Ko PC, Mei YY, Tang WC, Kao YT, Cheng HY, Liang YC, Lin SY* (2014, Sep). MCPIP1 suppresses hepatitis C virus replication and negatively regulates virus-induced proinflammatory cytokine responses.. The Journal of Immunology, 193:4159-68.. (SCI, 24/144, Immunology). MOST 100-2320-B-038-033.
  • Chuan-Hsiao Han, Yin-Shiou Lin, Shyr-Yi Lin*, Wen-Chi Hou (2014, Jan). Antioxidant and antiglycation activities of the synthesised dipeptide,Asn-Trp, derived from computer-aided simulation of yam dioscorin hydrolysis and its analogue, Gln-Trp. Food Chemistry, 147, 195-202.
  • Han CH, Lin YF, Lin YS, Lee TL, Huang WJ, Lin SY*, Hou WC (2014, Jan). Effects of yam tuber protein, dioscorin, on attenuating oxidative status and learning dysfunction in D-galactose-induced BALB/c mice.. Food and Chemical Toxicology, (65),356-363.
  • C.S. Lin, S.Y. Lin, C.C. Chang, H.H. Wang, C.C. Liao, T.L. Chen (2013, Dec). Postoperative adverse outcomes after non-hepatic surgery in patients with liver cirrhosis. British Journal of Surgery, 100, 1784-1790.
  • Ren-Jye Lin*, Hsu-Ling Chien, Shyr-Yi Lin, Bi-Lan Chang, Han-Pang Yu, Wei-Chun Tang, Yi-Ling Lin* (2013, Jan). MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation. NUCLEIC ACIDS RESEARCH. (Accepted). (SCI, 26/290, biochemistry and molecular biology).
  • Shyr-Yi LIN, Hsueh-Lian TENG, Sung-Hui TSENG, Lih-Geeng CHEN, Ching-Chiung WANG (2012, Dec). The antinociceptive and anti-inflammatory activities of Petasites formosanus Kitamura extract. Botanical Studies, 53: 431-438.. (SCI, 108/190, Plant Science).
  • Shyr-Yi Lin, Woan-Ruoh Lee, Yi-Fan Su, Sung-Po Hsu, Hsu-Chen Lin, Pei-Yin Ho, Tien-Chi Hou, Yu-Pei Chou, Chun- Ting Kuo & Wen-Sen Lee (2012, Dec). Folic acid inhibits endothelial cell proliferation through activating the cSrc/ ERK 2/NF-κB/p53 pathway mediated by folic acid receptor. Angiogenesis, 15:671–683. (SCI, 6/68, peripheral vascular disease). NSC 96-2320-B-038-023.