Shy-Shin Chang M.D., PhD.

Family Medicine

-Molecular microbiology
-Obesity medicine and weight control
-Preventive Medicine and evidence-based medicine
-Emergency Medicine and critical medicine

-English/ Chinese


    -Molecular microbiology

    -Obesity medicine and weight control

    -Preventive Medicine and evidence-based medicine

    -Emergency Medicine and critical medicine


-The member of the association of family medicine of ROC, No. 3863

-The member of the society of emergency medicine, Taiwan, No. A269

-The member of the society of emergency and critical care medicine, Taiwan, No. 2880

-The member of American college of emergency physicians

-The member of the society of ultrasound in medicine of ROC, No.006533


-The member of the teaching and training committee, Taipei Association of Family Medicine

     -The member of the Food and Drug Administration, Taiwan


-2016 the Marquis Who’s Who Publication Board



1: Lee CC, Lee MG, Lee WC, Lai CC, Chao CC, Hsu WH, Chang SS, Lee M. Preadmission Use of Calcium Channel Blocking Agents Is Associated With Improved Outcomes in Patients With Sepsis: A Population-Based Propensity Score-Matched Cohort Study. Crit Care Med. 2017 Sep;45(9):1500-1508.

2: Wu CW, Wu JY, Lee MG, Lai CC, Wu IL, Tsai YW, Chang SS**, Lee CC. Risk of

incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study. BMC Pulm Med. 2017 May


3: Hsu WT, Esmaily-Fard A, Lai CC, Zala D, Lee SH, Chang SS, Lee CC.

Antipsychotics and the Risk of Cerebrovascular Accident: A Systematic Review and

Meta-Analysis of Observational Studies. J Am Med Dir Assoc. 2017 Aug 1;18(8):692-699.

4: Lee SH, Hsu WT, Lai CC, Esmaily-Fard A, Tsai YW, Chiu CC, Wang J, Chang SS**, Lee CC. Erratum to: Use of antipsychotics increases the risk of fracture: a

systematic review and meta-analysis. Osteoporos Int. 2017 May;28(5):1763.

5: Hung WS, Ling P, Cheng JC, Chang SS, Tseng CP. Disabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization

and signaling. Sci Rep. 2016 Oct 17;6:35343.

6: Wu JY, Lee MT, Lee SH, Lee SH, Tsai YW, Hsu SC, Chang SS**, Lee CC.

Angiotensin-Converting Enzyme Inhibitors and Active Tuberculosis: A

Population-Based Study. Medicine (Baltimore). 2016 May;95(19):e3579.

7: Lai CC, Lee MT, Lee SH, Hsu WT, Chang SS, Chen SC, Lee CC. Statin treatment is associated with a decreased risk of active tuberculosis: an analysis of a nationally representative cohort. Thorax. 2016 Jul;71(7):646-51.

8. Tsai YW, Lu MC, Lin YH, Lee YC, Li WC, Chen JY, Chang SS*. Combined body mass index with high-sensitivity C-reactive protein as independent predictors for chronic kidney disease in a relatively healthy population in Taiwan European Journal of Clinical Nutrition (2016) 70, 766–771.

9: Chen YS, Gi WT, Liao TY, Lee MT, Lee SH, Hsu WT, Chang SS**, Lee CC. Using the galectin-3 test to predict mortality in heart failure patients: a systematic review and meta-analysis. Biomark Med. 2016;10(3):329-42.

10: Lee MT, Lee SH, Chang SS, Chan YL, Pang L, Hsu SM, Lee CC. Comparative

Treatment Failure Rates of Respiratory Fluoroquinolones or β-Lactam + Macrolide

Versus β-Lactam Alone in the Treatment for Community-Acquired Pneumonia in Adult Outpatients: An Analysis of a Nationally Representative Claims Database. Medicine(Baltimore). 2015 Sep;94(39):e1662.

11: Lee CC, Chang SS, Lee SH, Chen YS, Hsu WT, Gabriel Lee MT. Use of nicorandil is Associated with Increased Risk for Gastrointestinal Ulceration and

Perforation- A Nationally Representative Population-based study. Sci Rep. 2015

Jun 29;5:11495.

12: Chang SS, Lai CC, Lee MT, Lee YC, Tsai YW, Hsu WT, Lee CC. Risk of

spontaneous bacterial peritonitis associated with gastric Acid suppression. Medicine (Baltimore). 2015 Jun;94(22):e944.

13: Lin KH, Chang SS, Yu CW, Lin SC, Liu SC, Chao HY, Lee MT, Wu JY, Lee CC.

Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis. BMJ Open. 2015 Apr 14;5(4):e006703.

14: Wu CW, Wu JY, Chen CK, Huang SL, Hsu SC, Lee MT, Chang SS**, Lee CC. Does procalcitonin, C-reactive protein, or interleukin-6 test have a role in the

diagnosis of severe infection in patients with febrile neutropenia? A systematic

review and meta-analysis. Support Care Cancer. 2015 Oct;23(10):2863-72.

15: Tseng JC, Li CH, Chen KF, Chan YL, Chang SS, Wang FL, Chiu TF, Chen JC.

Outcomes of an emergency department intensive care unit in a tertiary medical

center in Taiwan: An observational study. J Crit Care. 2015 Jun;30(3):444-8.

16: Lee MT, Lee SH, Chang SS, Lee SH, Lee M, Fang CC, Chen SC, Lee CC.

Comparative effectiveness of different oral antibiotics regimens for treatment of

urinary tract infection in outpatients: an analysis of national representative

claims database. Medicine (Baltimore). 2014 Dec;93(28):e304.

17: Yo CH, Lee MT, Gi WT, Chang SS, Tsai KC, Chen SC, Lee CC. Prognostic

determinants of community-acquired bloodstream infection in type 2 diabetic patients in ED. Am J Emerg Med. 2014 Dec;32(12):1450-4.

18: Chu HC, Tseng WL, Lee HY, Cheng JC, Chang SS, Yung BY, Tseng CP. Distinct

effects of Disabled-2 on transferrin uptake in different cell types and culture conditions. Cell Biol Int. 2014 Nov;38(11):1252-9.

19: Young YR, Sheu BF, Li WC, Hsieh TM, Hung CW, Chang SS**, Lee CC. Predictive value of plasma brain natriuretic peptide for postoperative cardiac

complications--a systemic review and meta-analysis. J Crit Care. 2014 Aug;29(4):696.e1-10.

20: Lee CC, Lee MT, Chang SS, Lee SH, Huang YC, Yo CH, Lee SH, Chen SC. A

comparison of vasopressin, terlipressin, and lactated ringers for resuscitation

of uncontrolled hemorrhagic shock in an animal model. PLoS One. 2014 Apr 23;9(4):e95821.

21: Yo CH, Lee SH, Chang SS, Lee MC, Lee CC. Value of high-sensitivity C-reactive

protein assays in predicting atrial fibrillation recurrence: a systematic review and meta-analysis. BMJ Open. 2014 Feb 20;4(2):e004418.

22: Lee SH, Chan RC, Chang SS, Tan YL, Chang KH, Lee MC, Chang HE, Lee CC. Use of bisphosphonates and the risk of osteonecrosis among cancer patients: a systemic review and meta-analysis of the observational studies. Support Care Cancer. 2014  Feb;22(2):553-60.

23: Chang SS, Hsieh WH, Liu TS, Lee SH, Wang CH, Chou HC, Yeo YH, Tseng CP, Lee CC. Multiplex PCR system for rapid detection of pathogens in patients with

presumed sepsis - a systemic review and meta-analysis. PLoS One. 2013 May


24. Su H, Chang SS, Han CM, Wu KY, Li MC, Huang CY, Lee CL, Wu JY, Lee CC. Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis-a systemic review and meta-analysis. J Perinatol. 2014 Apr;34(4):268-74.

25. Hsu SC, Chang SS, Lee Mengtse Gabriel, Tsai YW, Lin SC, Weng YC, Lorenzo Porta , Wu JY, Lee CC .Risk of Gastrointestinal Perforation in Patients Taking Oral Fluoroquinolone Therapy: an analysis of nationally representative cohort
 PLoS One. 2017 

26. Chen YC, Lai SH, Tsai YW, Chang SS**. Visceral Adiposity Index as a Predictor of Chronic Kidney Disease in a Relatively Healthy Population in Taiwan. Journal of renal nutrition