Pai-Chien Chou, MD PhD

Pulmonary Medicine

SPECIALTY/PRACTICE AREAS：
• Asthma and COPD
• Allergy
• Lung cancer
• AI in medicine
LANGUAGES SPOKEN：
• English
• Chinese

 

PROFESSIONAL EDUCATION：

• M.D. Taipei Medical University
• PhD. Imperial College, London, United Kingdom

 

ADMINSTRATIVE APPOINTMENTS：

• Director, Department of Pulmonary Medicine Taipei Medical University Hospital

 

PUBLICATIONS：

• Chou PC, Lin CL, Liu WT, Lin HC, Kuo HP*. Safety of the Methacholine Challenge Test in Patients with Severe Airway Obstruction; Thoracic medicine; 2003, 18, 329-337 (專科醫學會期刊)
• Liu CY, Chung PI, Chou CL, Lin SM, Chen HC, Chou PC, Liu YH, Yu CT, Wang CH, Lin HC, Kuo HP. Cytoprotective Response of A1, a Bcl-2 Homologue Expressed in Mature Human Neutrophils and Promyelocytic HL-60 Cells, to Oxidant Stress-Induced Cell Death. Journal of Biomedical Science; Mar/Apr 2004, Vol. 11 Issue 2, p214.
• Liu CY, Lin HC, Yu CT, Lin SM, Lee KY, Chen HC, Chou CL, Huang CD, Chou PC, Liu WT, Wang CH, Kuo HP*. The concentration-dependent chemokine release and pro-apoptotic effects of neutrophil-derived alpha-defensin-1 on human bronchial and alveolar epithelial cells. . Life Sci. 2007 Jan 30;80(8):749-58. (SCI; IF=2.527; MEDICINE, RESEARCH & EXPERIMENTAL, 47/112)
• Chou CL, Chiang LL, Yu CT, Chen HC, Lee KY, Lin SM, Huang CD, Liu WT, Chou PC, Wang CH, Lin HC, Kuo HP, Liu CY*. Apoptosis-dependent and -independent mechanisms mediate the phagocytic recognition/clearance of the HL60-A1 transfectants with prolonged survival. Inflamm Res. 2007 May;56(5):195-203. (SCI; IF=2.109; CELL BIOLOGY, 128/181)
• Wort SJ, Ito M, Chou PC, Mc Master SK, Badiger R, Jazrawi E, de Souza P, Evans TW, Mitchell JA, Pinhu L, Ito K, Adcock IM*. Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. J Biol Chem. 2009 ;284:24297-305. (SCI; IF=4.773; BIOCHEMISTRY & MOLECULAR BIOLOGY, 66/290)
• Charron CE, Chou PC, Coutts DJ, Kumar V, To M, Akashi K, Pinhu L, Griffiths M, Adcock IM, Barnes PJ, Ito K*. Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription; J Biol Chem. 2009;284:36047-54. (SCI; IF=4.773; BIOCHEMISTRY & MOLECULAR BIOLOGY, 66/290)
• Adcock IM, Chou PC, Durham A, Ford P*. Overcoming steroid unresponsiveness in airways disease. Biochem Soc Trans. 2009;37(Pt 4):824-9 (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY, 94/290)
• Durham A, Chou PC, Kirkham P, Adcock IM*. Epigenetics in asthma and other inflammatory lung diseases; Epigenomics; 2010,2(4):523-537 (SCI; GENETICS & HEREDITY, 92/158)
• Chou PC, Lin SM, Lo CY, Chen HC, Wang CW, Chou CL, Yu CT, Lin HC, Wang CH, Kuo HP*. Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer. PLOS One. 7(10): e47613. (SCI; Biology, 12/85)
• Chou PC, Wang CH, Huang CD, Lo YL, Lee KY, Yu CT, Lin SM, Lin HC, Kuo HP*. Nucleic acid amplification test and bronchoscopy improve the diagnostic accuracy of smear-negative tuberculosis. The international journal of Tuberculosis and Lung disease. 2012; Dec;16 (12):1674-9. (SCI; RESPIRATORY SYSTEM, 18/48)
• Chen LF, Wang CH, Chou PC, Ho SC, Joa WC, Sheng TF, Kuo HP*. Association Between Emphysema Score, Six-Minute Walk and Cardiopulmonary Exercise Tests in COPD. The Open Respiratory Medicine Journal, 2012, 6, 104-110
• Wang TY, Lo YL, Liu WT, Lin SM, Lin TY, Kuo CH, Chung FT, Chou PC, Chang PJ, Ni YL, Ho SC, Lin HC, Wang CH, Yu CT, Kuo HP. Chronic cough and obstructive sleep apnoea in a sleep laboratory-based pulmonary practice. Cough 2013 5;9(1):24. Epub 2013 Nov 5.
• Hsieh MH, Chou PC, et al. Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan. PLOS One. 2012; 8(6): e66265. (SCI; Biology, 12/85) (Co-first author)
• Wang TY, Lin SM, Shie SS, Chou PC, Huang CD, Chung FT, Kuo CH, Chang PJ, Kuo HP. Clinical Characteristics and Treatment Outcomes of Patients with Low- and High-Concentration Isoniazid-Monoresistant Tuberculosis. PLoS One. 2014; 9(1): e86316.
• Chiu KC, Chou YL, Hsu JY, Lin MS, Lin CH, Chou PC, Chou CL, Wang CH, Kuo HP. Comparison of the efficacy of ciclesonide with budesonide in mild to moderate asthma patients after step-down therapy. NPJ Prim Care Respir Med 2014 20;24:14010. Epub 2014 May 20.
• Dongmin Shao, Frédéric Perros, Gaetano Caramori, Chao Meng, Peter Dormuller, Chou PC, Colin Church, Alberto Papi, Paolo Casolari, David Welsh, Andrew Peacock, Marc Humbert, Ian M Adcock, Stephen J Wort. Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension. Biochem Biophys Res Commun 2014 Aug 5;451(1):8-14. Epub 2014 Jul 5.
• Wang CH, Chou PC, Joa WC, Chen LF, Sheng TF, Ho SC, Lin HC, Huang CD, Chung FT, Chung KF, Kuo HP. Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study. BMC Pulm Med 2014 30;14:142. Epub 2014 Aug 30.
• Wang CH, Tushar Harishchandra Punde, Huang CD, Chou PC, Huang JT, Wu WH, Liu CH, Chung KF, Kuo HP(2014, Oct). Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation.. Journal of Allergy and Clinical Immunology, epub ahead of print. (SCI, 1/21, ALLERGY).
• Wang TY, Lo YL, Chou PC, Chung FT, Lin SM, Lin TY, Lin HC, Wang CH, Yu CT, Kuo HP. Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2015 29;10:231-7. Epub 2015 Jan 29.
• Ho TY, Chou PC, Yang CT, Tsang NM, Yen TC. Total Lesion Glycolysis Determined per RECIST 1.1 Criteria Predicts Survival in EGFR Mutation-Negative Patients With Advanced Lung Adenocarcinoma. Clin Nucl Med 2015 Mar 17. Epub 2015 Mar 17 (Co-first author)
• Lin SM, Chung FT, Kuo CH, Chou PC, Wang TY, Chang PJ, Lo YL, Huang CD, Lin HC, Wang CH, Kuo HP. Circulating angiopopietin-1 correlates with the clinical course of multiple organ dysfunction syndrome and mortality in patients with severe sepsis. Medicine (Baltimore) 2015 May;94(20):e878
• Huang SY, Chou PC, Wang TY, Lo YL, Joa WC, Chen LF, Sheng TF, Chung KF, Wang CH, Kuo HP. Exercise-Induced Changes in Exhaled NO Differentiates Asthma With or Without Fixed Airway Obstruction From COPD With Dynamic Hyperinflation. Medicine (Baltimore) 2016 Apr;95(15):e3400
• Wang TY, Hung CY, Shie SS, Chou PC, Kuo CH, Chung FT, Lo YL, Lin SM. The clinical outcomes and predictive factors for in-hospital mortality in non-neutropenic patients with candidemia. Medicine (Baltimore) 2016 Jun;95(23):e3834
• Huang HY, Chou PC, Joa WC, Chen LY, Sheng TF, Lin HC, Yang LF, Pan YB, Chung FT, Wang CH, Kuo HP. Pulmonary rehabilitation coupled with negative pressure ventilation decreases decline in lung function, hospitalizations, and medical cost in COPD: A 5-year study. Medicine (Baltimore) 2016 Oct;95(41):e5119
• Wang CH, Chou PC, Chung FT, Lin HC, Huang KH, Kuo HP. Heat shock protein70 is implicated in modulating NF-κB activation in alveolar macrophages of patients with active pulmonary tuberculosis. Sci Rep 2017 Apr 27;7(1):1214. Epub 2017 Apr 27
• Yang SC, Wu CH, Tu YK, Huang SY, Chou PC. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin increases the activation of aryl hydrocarbon receptor and associated with the aggressiveness of osteosarcoma MG-63 osteoblast-like cells. Oncology Letter, 2018 Sep;16(3):3849-3857 (Corresponder)